APC-independent NK cell activation.
نویسندگان
چکیده
منابع مشابه
Impaired NK cell function in ESRD patients.
(humoral immune response). Alternatively, if IL-12 and IL-18 are predominant, a Th1 response is initiated leading to the secretion of IL-2 and interferon (IFN) and the stimulation of cytotoxic T cells and NK cells (cellular immune response). Several studies in patients with ESRD demonstrated the preactivation of circulating monocytes [2, 3] . The Th1 response may be disturbed on the level of a...
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Initiation of the adaptive immune response is dependent on the priming of naive T cells by APCs. Proteomic analysis of unactivated and activated human NK cell membrane-enriched fractions demonstrated that activated NK cells can efficiently stimulate T cells, since they upregulate MHC class II molecules and multiple ligands for TCR costimulatory molecules. Furthermore, by manipulating antigen ad...
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Toll-like receptors (TLRs) play a fundamental role in the recognition of bacteria and viruses. TLR3 is activated by viral dsRNA and polyinosinic-polycytidylic acid (poly(I:C)), a synthetic mimetic of viral RNA. We show that NK cells, known for their capacity to eliminate virally infected cells, express TLR3 and up-regulate TLR3 mRNA upon poly(I:C) stimulation. Treatment of highly purified NK ce...
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Natural Killer (NK) cells are the main lymphocyte population expressing P75 B chain of the IL-2 receptor (IL-2R). Consequently, incubation of peripheral blood lymphocytes with IL-2 induce selective activation of NK cells and results in NK activity and generation of Lymphokine activated killer (LAK) cells activity and proliferation. One of the early events during IL-2 activation of peripheral bl...
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ورودعنوان ژورنال:
- Journal of immunology
دوره 175 4 شماره
صفحات -
تاریخ انتشار 2005